Identification of characteristic salivary proteins from disease mouse and application on diagnosis of xerostomia

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We determined the proteins showing characteristic expression in parotid glands from non-obese diabetic (NOD) mouse which shows autoimmune diabetes and is used as a model for Sjogren syndrome. Chitinase was selected by cDNA microarray analysis as a characteristic secretory protein. Chitinase was expressed in the parotid glands and secreted in saliva. After diabetes onset, the expression of chitinase was increased in the parotid glands and the concentration of chitinase in saliva was increased.