Molecular regulation system of cytodifferentiation due to mechanical stress

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Early changes of Runx2 and Msx2 expressions were examined by immunohistochemistry in mouse periodontal ligament exposed to mechanical stress. Expressions of Runx2, BMP and HSP became stronger in parallel with time, the periodontal fibroblasts, cementoblasts as well as osteoblasts showed strong expression. Moreover, ALP has also demonstrated similar strong expression. All these results strongly suggested that Runx2 promoted differentiation of osteoblasts at early stage and Msx2 worked as an activator of Runx2 function. Furthermore, it also suggests that these HSP act as molecular chaperones for osteoblast activation and maintenance.