Role of Ten-m/Odz3 in the formation, growth and functional maintenance of mandibular condylar cartilage

Ten-m/Odz3在下颌髁软骨形成、生长和功能维持中的作用

• 批准号: 20592408
• 负责人: FUKUNAGA Tomohiro
• 金额: $ 3万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592408/
• 关键词: マウス下顎頭軟骨; Ten-m; Odz3; 細胞分化; 遺伝子発現; Ten-m/Odz3; odz3

The mandibular condyle has been speculated to develop via the differentiation of the fibroblast-like cells covering the condyle into chondrocytes ; however, the developmental mechanisms behind this process have not been revealed. We describe the temporal and spatial expression of Ten-m/Odz3 mRNA as determined by in situ hybridization in mouse mandibular condylar cartilage of 1 day, 1 week, and 3 week of age during the early stages of development. Ten-m/Odz3 was expressed in the fibrous layer and the proliferating and mature chondrocyte layers, but was not detected in the hypertrophic chondrocyte layer. Furthermore, we evaluated the in vitro expression of Ten-m/Odz3 using ATDC5 cells, a mouse chondrogenic cell line. Ten-m/Odz3 was expressed during the early stage of the differentiation of mesenchymal cells into chondrocytes. These findings suggest that Ten-m/Odz3 is involved in the differentiation of chondrocytes and that it acts as a regulatory factor in the early stages of the development of mandibular condylar cartilage.

下颌髁突被推测是通过覆盖在髁突上的成纤维细胞样细胞向软骨细胞分化而发育的；然而，这一过程背后的发育机制尚未揭示。我们描述了10 -m/Odz3 mRNA的时间和空间表达，通过原位杂交测定1天，1周和3周龄的小鼠下颌髁软骨在早期发育阶段。Ten-m/Odz3在纤维层和增殖成熟软骨细胞层中表达，而在增生性软骨细胞层中未检测到。此外，我们使用小鼠软骨细胞ATDC5细胞评估了Ten-m/Odz3的体外表达。Ten-m/Odz3在间充质细胞向软骨细胞分化的早期表达。这些发现表明，Ten-m/Odz3参与软骨细胞的分化，并在下颌髁软骨发育的早期阶段起调节作用。

项目成果

A case of mandibular deviation and canted maxillary occlusal plane treated with miniscrews and IVRO : Functional and morphological changes

微型螺钉和 IVRO 治疗下颌偏斜和上颌咬合面倾斜一例：功能和形态变化

• 发表时间: 2009
• 期刊: Am J Orthod Dentofacial Orthop 136
• 作者: Sakai Y;Balam TA;Kuroda S;Tamamura N;Fukunaga T;Takigawa M;Takano-Yamamoto T;Sakai Y;Okamoto A;Taira K;Hashimoto T
• 通讯作者: Hashimoto T

Dental and craniofacial characteristics in a patient with leprechaunism treated with IGF-I.

使用 IGF-I 治疗的小妖精患者的牙齿和颅面特征。

• 发表时间: 2008
• 期刊: Angle Orthod 78
• 作者: Fukunaga T;Murakami T;Tanaka H;Miyawaki S;Yamashiro T;Takano-Yamamoto T
• 通讯作者: Takano-Yamamoto T

CTGF and Apoptosis in Mice Osteocytes Induced by Tooth Movement

牙齿移动诱导的小鼠骨细胞CTGF和细胞凋亡

• 发表时间: 2009
• 期刊: Journal of Dental Research (印刷中)
• 作者: Yuichi Sakai;Tarek A. Balam;Shingo Kuroda;Nagato Tamamura;Tomohiro Fukunaga;Masaharu Takigawa;Teruko Takano-Yamamoto
• 通讯作者: Teruko Takano-Yamamoto

Effects of mandibular advancement plus prohibition of lower incisor movement on mandibular growth in rat

下颌前移加禁止下切牙运动对大鼠下颌生长的影响

• 发表时间: 2009
• 期刊: Angle Orthodontist 79
• 作者: Sakai Y;Balam TA;Kuroda S;Tamamura N;Fukunaga T;Takigawa M;Takano-Yamamoto T;Sakai Y;Okamoto A;Taira K
• 通讯作者: Taira K

成人両側性口唇口蓋裂症例の形態的、機能的改善と長期保定

成人双侧唇腭裂病例的形态和功能改善及长期保留

• 发表时间: 2010
• 作者: 福永智広;本城正;酒井雄一;山本照子;山城隆
• 通讯作者: 山城隆