Usefulness of LL37 as a multifunctional molecule for prevention of periodontal disease and periodontal tissue regeneration

点击翻译按钮获取中文摘要

LL37, which has antibacterial activity against cariogenic and periodontopathogenic bacteria abolished the increase in the factor involved in inflammation induced by periodontopathogenic bacteria. LL37 enhanced the production of the factor involved in angiogenesis. Furthermore, LL37 promoted the new bone formation in the rat experimentally created calvarial bone defect. Thus, in addition to antibacterial activity, LL37 is found to possess anti-inflammatory action, angiogenic activity and osteogenic activity, suggesting LL37 is possible to be useful for prevention of periodontal disease and periodontal tissue regeneration.