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A study on the effects of products from non-hemocyte cells activated by crosslinking HLA-II molecules on Th-cell differentiation in periodontal diseases

A study on the effects of products from non-hemocyte cells activated by crosslinking HLA-II molecules on Th-cell differentiation in periodontal diseases
交联HLA-II分子激活的非血细胞产物对牙周病Th细胞分化影响的研究
批准号:
20592443
负责人:
OHYAMA Hideki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In the study to examine the effects of products from human gingival fibroblasts (HGF) activated by cross-linking HLA-II molecules on Th-cell response and differentiation, we found that Th cells exhibited a Th2-shifted phenotype after mixed lymphocyte reaction culture between naive T cells and allogeneic DCs in the presence of culture supernatant from HGF stimulated via HLA-DQ molecules. The regulation of Th2 polarization in Th-cells could be partially attributed to the activation of DCs being affected by PGE_2 produced from HGF stimulated via HLA-DQ.
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IFN-γ低産生関連IL-12R β2遺伝子プロモーター領域の多型とその検出方法
IL-12R β2 基因启动子区与 IFN-γ 低产量相关的多态性及其检测方法
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: []
通讯作者:
Differential effect of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cll activity.
IL12RB2 5侧翼区域多态性对 NK-和 T-cll 活性的差异影响。
DOI: --
发表时间: 2008
期刊: J.Interferon Cytokine Res. 28
影响因子: --
作者: [Ohyama H., Kato-Kogoe N., Nishimura F., Takeuchi-Hatanaka K., Matsushita S., Yamanegi K., Yamada N., Hata M., Nakasho K., Terada N.]
通讯作者: Terada N.
Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.
IL12RB2 5 侧翼区域多态性对 NK 细胞和 T 细胞活性的差异影响。
DOI: --
发表时间: 2008
期刊: J Interferon Cytokine Res. 28(9)
影响因子: --
作者: [Ohyama H, Kato-Kogoe N, Nishimura F, Takeuchi-Hatanaka K, Matsushita S, Yamanegi K, Yamada N, Hata M, Nakasho K, Terada N]
通讯作者: Terada N
短期集中的な口腔衛生管理により重度白血病性歯肉炎の軽快を見た急性骨髄性白血病患者の1症例
急性髓系白血病患者短期强化口腔卫生管理后严重白血病牙龈炎好转一例
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Majerciak V., Yamanegi K., Allemand E., Kruhlak M., Krainer A.R., Zheng Z.M., Hideki Ohyama, 蔵下舞,大山秀樹,木崎久美子,橋谷進]
通讯作者: 蔵下舞,大山秀樹,木崎久美子,橋谷進
37
    A study for the involvement of IL-22 in the pathogenesis of periodontal diseases
    • 批准号:
      18592274
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      OHYAMA Hideki
    • 依托单位:
    A basic studies to develop the immune therapy for periodontal diseases by employing glycolipids derived from periodontal bacteria as antigens.
    海外基金