Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus

以健康志愿者为对照，研究糖尿病患者呼出空气中丙酮、挥发性硫化合物及口腔空气中丙酮的含量，分析糖尿病患者一般状况与口腔环境的关系。住院期间，2型糖尿病患者呼气及口腔空气中丙酮含量随血糖改善而降低。对口腔状况良好的健康志愿者的研究表明，呼出空气中的丙酮与空腹过夜后血浆中的乙酰乙酸或3-羟基丁酸有显著的强相关性。丙酮与挥发性硫化合物之间无显著相关性。本研究提示无创丙酮检测可能提示血浆中酮体，反映糖尿病的病理状况。

We studied acetone in exhaled air, volatile sulfur compounds and acetone in mouth air, to analyze relation between general condition and oral environment of patients with diabetes mellitus, with healthy volunteers as control. Acetone in exhaled and mouth air of type 2 diabetes patients decreased with improvement of plasma glucose during hospitalization. Study of healthy volunteers with good oral condition showed significantly strong correlation between acetone in exhaled air and acetoacetic acid or 3-hydroxybutyric acid in plasma after fasting overnight. There was no significant correlation between acetone and volatile sulfur compounds. This study suggests possibility that non-invasive acetone measuring indicates ketone bodies in plasma, which reflect pathologic condition of diabetes mellitus.