Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus

挥发性气体二维评价糖尿病口腔状况

• 批准号: 20592447
• 负责人: TANDA Naoko
• 金额: $ 3.08万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592447/
• 关键词: 予防歯科学; 糖尿病; 口内気体; 二次元評価; 血糖; アセトン; 揮発性硫黄化合物; ケトン体; 口腔環境; 呼気; 口臭; 口腔内環境

We studied acetone in exhaled air, volatile sulfur compounds and acetone in mouth air, to analyze relation between general condition and oral environment of patients with diabetes mellitus, with healthy volunteers as control. Acetone in exhaled and mouth air of type 2 diabetes patients decreased with improvement of plasma glucose during hospitalization. Study of healthy volunteers with good oral condition showed significantly strong correlation between acetone in exhaled air and acetoacetic acid or 3-hydroxybutyric acid in plasma after fasting overnight. There was no significant correlation between acetone and volatile sulfur compounds. This study suggests possibility that non-invasive acetone measuring indicates ketone bodies in plasma, which reflect pathologic condition of diabetes mellitus.

通过对呼出空气中丙酮、口腔空气中挥发性硫化物和丙酮的检测，分析糖尿病患者一般情况与口腔环境的关系，并以健康志愿者为对照。2型糖尿病患者入院期间呼气和口腔空气中的丙酮随着血糖的改善而降低。对口腔状况良好的健康志愿者的研究表明，禁食一夜后呼出空气中的丙酮与血浆中的乙酰乙酸或3-羟基丁酸之间存在显著的相关性。丙酮与挥发性硫化物之间没有显著的相关性。本研究提示无创性丙酮测定提示血浆中有酮体存在的可能性，可反映糖尿病的病理状态。

项目成果

入院中に口腔環境改善を試みた治療コンプライアンスの低い2型糖尿病の1例

治疗依从性差的2型糖尿病患者住院期间尝试改善口腔环境1例。

• 发表时间: 2009
• 作者: 丹田奈緒子;檜尾好徳;由浪有希子;鷲尾純平;高橋信博;小関健由;片桐秀樹;岡芳知
• 通讯作者: 岡芳知

Breath acetone in type 1 and type 2 diabetes mellitus

1 型和 2 型糖尿病患者呼吸丙酮

• 发表时间: 2011
• 作者: 丹田奈緒子;檜尾好徳;鷲尾純平;高橋信博;小関健由
• 通讯作者: 小関健由

Acetone in Mouth Air in Type 2 Diabetes Mellitus

2 型糖尿病患者口腔空气中的丙酮

• 发表时间: 2010
• 作者: 丹田奈緒子;檜尾好徳;鷲尾純平;高橋信博;小関健由
• 通讯作者: 小関健由