Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus

通过对糖尿病患者呼出气中丙酮、口腔空气中挥发性硫化物及丙酮的检测，分析糖尿病患者口腔环境与一般情况的关系，并以健康志愿者为对照。2型糖尿病患者呼出气和口气中丙酮随住院期间血糖的改善而降低。对口腔健康志愿者的研究显示，禁食过夜后呼出气中丙酮与血浆中乙酰乙酸或3-羟基丁酸之间存在显著的强相关性。丙酮与挥发性硫化合物之间没有显著的相关性。本研究提示无创性丙酮测定可反映糖尿病患者血浆中酮体的变化，从而反映糖尿病的病理状态。

We studied acetone in exhaled air, volatile sulfur compounds and acetone in mouth air, to analyze relation between general condition and oral environment of patients with diabetes mellitus, with healthy volunteers as control. Acetone in exhaled and mouth air of type 2 diabetes patients decreased with improvement of plasma glucose during hospitalization. Study of healthy volunteers with good oral condition showed significantly strong correlation between acetone in exhaled air and acetoacetic acid or 3-hydroxybutyric acid in plasma after fasting overnight. There was no significant correlation between acetone and volatile sulfur compounds. This study suggests possibility that non-invasive acetone measuring indicates ketone bodies in plasma, which reflect pathologic condition of diabetes mellitus.