Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses

分析肺癌围手术期患者床边口腔护理前、口腔护理后、手术前及手术后呼出气体、口腔空气及唾液中的气体。术后观察患者的保护反射（咳嗽、吞咽反射）。对于术后无肺炎的患者，术前口腔护理增加了厌氧状态下唾液链球菌（通常称为健康相关菌）的比例。口腔护理也减少了唾液中的细菌总数，减少了恶臭气体。术后丙酮浓度升高，CRP快速升高。这项研究表明，床边无创测量挥发性硫化物和挥发性有机化合物可能表明围手术期肺癌的口腔环境和一般炎症状况。

We analyzed gasses from exhaled and mouth air and saliva of perioperative patients of lung cancer at bedside before oral care, after oral care before operation, and after operation. Protective reflexes (cough and swallowing reflex) were also measured before and after operation. As for patients without postoperative pneumonia, oral care before operation increased ratio of salivary streptococci, usually known as healthy-associated bacteria, in anaerobic condition. Oral care also decreased total number of bacteria in saliva and decreased malodorous gasses. Acetone concentration increased after operation with rapid increase of CRP.This study suggests possibility that non-invasive measuring volatile sulfide compounds and volatile organic compounds at bedside indicate oral environments and general inflammatory conditions of perioperative lung cancer.