Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses

基于呼吸气体二维分析的肺癌围术期患者口腔环境参数

• 批准号: 23593083
• 负责人: TANDA Naoko
• 金额: $ 3.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593083/
• 关键词: 周術期; 肺癌; 誤嚥性肺炎; 呼気; 口腔ケア; 口腔内細菌; 口内気体; 上気道反射; 口臭; 口腔細菌叢; 肺がん; 呼気分析; 周術期口腔ケア

We analyzed gasses from exhaled and mouth air and saliva of perioperative patients of lung cancer at bedside before oral care, after oral care before operation, and after operation. Protective reflexes (cough and swallowing reflex) were also measured before and after operation. As for patients without postoperative pneumonia, oral care before operation increased ratio of salivary streptococci, usually known as healthy-associated bacteria, in anaerobic condition. Oral care also decreased total number of bacteria in saliva and decreased malodorous gasses. Acetone concentration increased after operation with rapid increase of CRP.This study suggests possibility that non-invasive measuring volatile sulfide compounds and volatile organic compounds at bedside indicate oral environments and general inflammatory conditions of perioperative lung cancer.

我们对肺癌围手术期患者口腔护理前、术前口腔护理后和术后床边的呼出气体、口腔空气和唾液进行了分析。 手术前后还测量了保护性反射（咳嗽和吞咽反射）。 对于无术后肺炎的患者，术前口腔护理增加了厌氧条件下唾液链球菌（通常称为健康相关细菌）的比例。 口腔护理还可以减少唾液中的细菌总数并减少恶臭气体。 术后丙酮浓度随着CRP的快速升高而升高。本研究提示床边无创测量挥发性硫化物和挥发性有机化合物可能指示肺癌围手术期的口腔环境和一般炎症状况。

项目成果

Analysis of hydrogen sulfide, methyl mercaptan, and acetaldehyde in oral health care for perioperative patients of lung cancer

肺癌围术期患者口腔保健中硫化氢、甲硫醇、乙醛的分析

• 发表时间: 2013
• 作者: Tanda N;Ishida N;Hoshikawa Y;Sato T;Takahashi N;Hosokawa R;Koseki T
• 通讯作者: Koseki T

Hydrogen sulfide, methyl mercaptan, and acetaldehyde in oral health care for perioperative patients with pulmonary carcinoma

硫化氢、甲硫醇、乙醛在肺癌围术期患者口腔保健中的应用

• 发表时间: 2013
• 作者: Tanda N;Ishida N;Hoshikawa Y;Sato T;Takahashi N;Hosokawa R;Koseki T
• 通讯作者: Koseki T

Anasysis of hydrogen sulfide, methyl mercaptan, and acetaldehyde in oral health care for preoperative patients of lung cancer

肺癌术前口腔保健中硫化氢、甲硫醇、乙醛的分析

• 发表时间: 2013
• 作者: N.Tanda;N. Ishida;Y.Hoshikawa;T.Sato;N.Takahashi;R. Hosokawa;T. Koseki
• 通讯作者: T. Koseki