Mechanisms for the control of malignant properties of oral cacer with glyco-sphingolipids

点击翻译按钮获取中文摘要

It has been demonstrated that glycans on the cell surface was strongly involeved in malignant properties of oral squamous cell carcinomas and melanomas. Expression of Lewis y in oral squamous cell carcinomas resulted in attenuation of cancer malignant properties. As a mechanism, it was suggested that Lewis y might play roles in the negative regulation of the phosphorylation of EGFR. Furthermore, it was shown that majority of Yes was localized in GEM/rafts under GD3 expression in melanomas, resulting in the enhanced malignant properties by constitutive activation of Yes.