Fibrous adhesion of the intestine overcome by Oncostatin M gene therapy.

经放射治疗为腹部恶性肿瘤，正常肠进入受照射区后可引起肠炎和纤维化、腹痛、血性腹泻等原因。作者在肝损伤大鼠模型中应用抑癌素M （Oncostatin M， OSM）基因治疗试验，发现OSM具有抗炎和抗纤维化的作用[J] .中华病理学杂志，2001,17:872-881,2007。本研究通过对动物肠道纤维化模型进行OSM基因的表达，检验肠纤维化对肠上皮OSM基因治疗的有效性。与对照组相比，治疗组OSM基因被肠道功能衰竭抑制。OSM提示可能通过抗炎作用抑制纤维化。

By irradiation for abdominal malignancies, normal bowel into the irradiated area by bring radiation enteritis and fibrosis, abdominal pain, bloody diarrhea and causes. The applicant, a rat model of liver injury in Oncostatin M (OSM) gene therapy trial, OSM found that the effect of anti-inflammatory and anti-fibrosis (Am J Pathol. 171 : 872-881, 2007). In this study, the intestinal tract of animal models of fibrosis gene to OSM, examined for intestinal fibrosis intestinal epithelium OSM examined the usefulness of gene therapy. OSM gene was found in the treated group was suppressed by the failure of the intestinal tract compared with the control group. OSM suggesting the possibility that inhibition of fibrosis by anti-inflammatory effect.