Evaluation of pain related genes for patients with endometriosis

子宫内膜异位症与女性生殖健康的破坏有关，表现为盆腔疼痛和不孕不育。然而，子宫内膜异位症相关疼痛的机制仍不清楚。为了阐明子宫内膜异位症相关疼痛的分子机制，我们对腹水中神经生长因子(NGF)的浓度进行了研究。并对NGF和脂氧合酶相关基因的表达和定位进行了研究。NGF、5-lox和15-lox是子宫内膜异位病变局部产生的。这些局部表达的基因可能有助于急性和慢性盆腔疼痛的发生和维持，如痛经和性交困难。

Endometriosis is associated with disruption of women's reproductive health, in terms of pelvic pain and infertility. However mechanisms of endometriosis related pain still remain unclear. To obtain a clue to elucidate the molecular mechanisms underling the endometriosis related pain, we investigated the concentration of nerve growth factor (NGF) in ascites. The expression and localization of NGF and lipoxygenase related genes were also investigated. NGF, 5-lox, and 15-lox are locally produced from endometriotic lesion. These locally expressed genes may contribute to the generation and maintenance of acute and chronic pelvic pain, such as dysmenorrhea and dyspareunia.