The Cytochrome P450 Gene Super-family in Drosophila melanogaster; Gene Function and Insecticide Resistance

细胞色素P450 （Cyp）基因超家族在黑腹果蝇（Drosophila melanogaster）基因组中有90多个序列。迄今为止，已发现四种Cyp基因与杀虫剂抗性有关。大多数Cyp基因的功能尚不清楚。本项目将研究黑腹果蝇Cyp基因的功能和调控，将果蝇的基因型与其表型联系起来。通过研究Cyp基因对果蝇生存的影响、Cyp基因的表达和调控，以及在酵母表达系统中表达选定的Cyp基因，我们将加深对Cyp基因功能和进化的理解。

The cytochrome P450 (Cyp) gene super-family is represented by over 90 sequences in the genome of the vinegar fly, Drosophila melanogaster. To date, four Cyp genes are found to be involved in insecticide resistance. The function of the majority of Cyp genes is unknown. This project will investigate the function and regulation of D. melanogaster Cyp genes, linking the fly's genotype to its phenotype. By studying the effects of Cyp genes on fly survival, Cyp gene expression and regulation, and expressing selected Cyp genes in a yeast expression system, we will enhance our understanding of Cyp gene function and evolution.