Clarification of the mechanisms to control odor-evoked responses using genetically manipulated mice with neuronal modifications.

在这项研究中，我们发现，嗅球背侧区域的主嗅觉系统中的特定神经元回路，除了调节恐惧反应外，还调节各种社会交流反应。建立了主嗅觉系统特定神经元回路部分缺失的各种基因操作小鼠，并构建了气味诱发特定行为和情绪的定量分析系统。根据这些结果，我们建立了基于主嗅球中特定神经元回路的功能来研究调节气味诱发反应的神经机制的方法。

In this study, we found that specific neuronal circuits in the main olfactory system which start from distinct area on the dorsal-domain of the olfactory bulb regulate various social communication responses in addition to fear responses. Various kinds of genetically manipulated mice with partial depletions of the specific neuronal circuits in the main olfactory system were generated, and quantitative analysis systems for odor-evoked specific behaviors and emotions were constructed. From these results, we established the methods to study the neuronal mechanisms to regulate odor-evoked responses based on the functions of the specific neuronal circuits in the main olfactory bulb.