Clarification of the mechanisms to control odor-evoked responses using genetically manipulated mice with neuronal modifications.

在本研究中，我们发现在主嗅觉系统中，特定的神经回路从嗅球背域的不同区域开始，调节各种社交反应和恐惧反应。制备了主要嗅觉系统特定神经回路部分缺失的多种基因改造小鼠，构建了气味诱发特定行为和情绪的定量分析系统。在此基础上，我们建立了基于主嗅球特定神经回路功能研究气味诱发反应神经元调控机制的方法。

In this study, we found that specific neuronal circuits in the main olfactory system which start from distinct area on the dorsal-domain of the olfactory bulb regulate various social communication responses in addition to fear responses. Various kinds of genetically manipulated mice with partial depletions of the specific neuronal circuits in the main olfactory system were generated, and quantitative analysis systems for odor-evoked specific behaviors and emotions were constructed. From these results, we established the methods to study the neuronal mechanisms to regulate odor-evoked responses based on the functions of the specific neuronal circuits in the main olfactory bulb.