CREATION OF HYBRID CAPSULES WITH STIMULI-RESPONSIVE RELEASE PROPERTY

在过去的几十年里，微胶囊得到了广泛的研究，并在药物递送和化妆品工业领域引起了极大的兴趣。现在，人们正致力于开发具有刺激反应行为的“智能胶囊”。通过层层(LBL)技术和溶液法制备了一种用于无机材料合成的刺激响应型智能杂化微胶囊。利用溶胶-凝胶法制备的SiO_2-to_O2膜在聚电解质多层膜上成功地制备了紫外光响应型胶囊。在该体系中，囊壳被TiO2光催化反应破坏。这些胶囊通过控制SiO_2-to_O2层的组成，具有可调的紫外光触发释放功能。利用聚电解质、脂质双层和磁性纳米颗粒也制备了磁响应型智能胶囊。由于磁性纳米颗粒的加热导致脂膜中的相变，通过交变磁场的照射按需释放被包裹的材料。

Microcapsules have been widely investigated over the past few decades and have attracted great interest in the areas of drug delivery, and cosmetics industries. Now a number of efforts are devoted for the development of "smart capsules" with stimuli-responsive behavior. Stimuli-responsive smart hybrid microcapsules have been developed via the layer-by-layer (LbL) technique and the solution process for inorganic materials synthesis. UV-responsive capsules have been successfully prepared by using sol-gel derived SiO_2-TO_O2 layer on a polyelectrolyte multilayer shell. In this system, the capsular shell was ruptured by the photocatalytic reaction of TiO_2 component. These capsules have a tunable UV-triggered release function by control of composition of SiO_2-TO_O2 layer. Magnetoresponsive smart capsules have also fabricated using polyelectrolytes, lipid bilayers and magnetic nanoparticles. Encapsulated materials were released on-demand by irradiation with an alternating magnetic field, due to a phase transition in the lipid membrane, induced by heating of the magnetic nanoparticles.