CREATION OF HYBRID CAPSULES WITH STIMULI-RESPONSIVE RELEASE PROPERTY

微胶囊在过去几十年中得到了广泛的研究，并在药物递送和化妆品工业领域引起了极大的兴趣。现在，许多努力致力于开发具有刺激响应行为的“智能胶囊”。刺激响应智能杂化微胶囊已经通过层层（LbL）技术和无机材料合成的溶液过程开发。采用溶胶-凝胶法制备了SiO_2-TO_O_2多层壳结构的紫外光响应胶囊。在该体系中，TiO_2组分的光催化反应使囊壳破裂。通过控制SiO_2-TO_O_2层的组成，这些胶囊具有可调的紫外触发释放功能。磁响应智能胶囊也已经使用聚电解质、脂质双层和磁性纳米颗粒制造。封装的材料通过用交变磁场照射按需释放，这是由于加热磁性纳米颗粒引起的脂质膜中的相变。

Microcapsules have been widely investigated over the past few decades and have attracted great interest in the areas of drug delivery, and cosmetics industries. Now a number of efforts are devoted for the development of "smart capsules" with stimuli-responsive behavior. Stimuli-responsive smart hybrid microcapsules have been developed via the layer-by-layer (LbL) technique and the solution process for inorganic materials synthesis. UV-responsive capsules have been successfully prepared by using sol-gel derived SiO_2-TO_O2 layer on a polyelectrolyte multilayer shell. In this system, the capsular shell was ruptured by the photocatalytic reaction of TiO_2 component. These capsules have a tunable UV-triggered release function by control of composition of SiO_2-TO_O2 layer. Magnetoresponsive smart capsules have also fabricated using polyelectrolytes, lipid bilayers and magnetic nanoparticles. Encapsulated materials were released on-demand by irradiation with an alternating magnetic field, due to a phase transition in the lipid membrane, induced by heating of the magnetic nanoparticles.