CREATION OF HYBRID CAPSULES WITH STIMULI-RESPONSIVE RELEASE PROPERTY

具有刺激响应释放特性的混合胶囊的制备

• 批准号: 20686046
• 负责人: KATAGIRI Kiyofumi
• 金额: $ 13.89万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20686046/
• 关键词: 有機-無機複合体; チタニア; 交互積層法; 磁性ナノ粒子; 脂質二分子膜; 磁気ハイパーサーミア; 外部刺激応答材料; 薬物運搬体

Microcapsules have been widely investigated over the past few decades and have attracted great interest in the areas of drug delivery, and cosmetics industries. Now a number of efforts are devoted for the development of "smart capsules" with stimuli-responsive behavior. Stimuli-responsive smart hybrid microcapsules have been developed via the layer-by-layer (LbL) technique and the solution process for inorganic materials synthesis. UV-responsive capsules have been successfully prepared by using sol-gel derived SiO_2-TO_O2 layer on a polyelectrolyte multilayer shell. In this system, the capsular shell was ruptured by the photocatalytic reaction of TiO_2 component. These capsules have a tunable UV-triggered release function by control of composition of SiO_2-TO_O2 layer. Magnetoresponsive smart capsules have also fabricated using polyelectrolytes, lipid bilayers and magnetic nanoparticles. Encapsulated materials were released on-demand by irradiation with an alternating magnetic field, due to a phase transition in the lipid membrane, induced by heating of the magnetic nanoparticles.

微胶囊在过去几十年中得到了广泛的研究，并在药物递送和化妆品工业领域引起了极大的兴趣。现在，许多努力致力于开发具有刺激响应行为的“智能胶囊”。刺激响应智能杂化微胶囊已经通过层层（LbL）技术和无机材料合成的溶液过程开发。采用溶胶-凝胶法制备了SiO_2-TO_O_2多层壳结构的紫外光响应胶囊。在该体系中，TiO_2组分的光催化反应使囊壳破裂。通过控制SiO_2-TO_O_2层的组成，这些胶囊具有可调的紫外触发释放功能。磁响应智能胶囊也已经使用聚电解质、脂质双层和磁性纳米颗粒制造。封装的材料通过用交变磁场照射按需释放，这是由于加热磁性纳米颗粒引起的脂质膜中的相变。

项目成果

Tunable Magnetoresponsive Smart Hybrid Capsules Prepared via Layer-by-layer Assembly

通过层层组装制备可调谐磁响应智能混合胶囊

• 发表时间: 2010
• 作者: K. Katagiri;Y. Imai;M. Nakamura;K. Koumoto
• 通讯作者: K. Koumoto

Magneto-Responsive Hybrid Hollow Capsules Formed with Polyelectrolytes, Lipid Bilayers, and Fe3O4 Nanoparticles

由聚电解质、脂质双层和 Fe3O4 纳米颗粒形成的磁响应混合空心胶囊

• 发表时间: 2009
• 作者: K.Katagiri;M.Nakamura;Y.Imai;K.Koumoto
• 通讯作者: K.Koumoto

磁性ナノ粒子/脂質膜ハイブリッドカプセルの作製と磁場応答材料への展開

磁性纳米颗粒/脂膜杂化胶囊的制备及磁场响应材料的开发

• 发表时间: 2008
• 作者: 中村雅人;片桐清文;河本邦仁
• 通讯作者: 河本邦仁

ゾル-ゲル法技術の最新動向(作花済夫監修)

溶胶凝胶技术的最新趋势（由 Masao Sakuhana 监督）

• 发表时间: 2010
• 作者: 唯美津木;岩澤康裕;片桐清文(分担執筆)
• 通讯作者: 片桐清文(分担執筆)

Magnetoresponsive On-Demand Release of Hybrid Liposomes Formed from Fe_3O_4 Nanoparticles and Thermosensitive Block Copolymers Small

由 Fe_3O_4 纳米粒子和小热敏嵌段共聚物形成的混合脂质体的磁响应按需释放

• 发表时间: 2011
• 期刊: Small
• 影响因子: 13.3
• 作者: K.Katagiri;Y.Imai;K.Koumoto;T.Kaiden;K.Kono;S.Aoshima
• 通讯作者: S.Aoshima