Development of diagnostic imaging reagents based on designing and synthesizing fluorescent probes

活性氧（reactive oxygen species，ROS）作为信号分子在多种生理条件下发挥作用，ROS的过度产生与多种疾病的发生有关。因此，荧光探针是一种很有前途的工具，可以用来揭示生理和病理过程的分子机制，也可能用于诊断。我们开发了这样一种新的荧光探针，在生理上有利的近红外区。

Reactive oxygen species (ROS) operate as signaling molecules undervarious physiological conditions, and overproduction of ROS is involved in the pathogenesisof many diseases. Therefore, fluorescent probes for visualizing ROS are promising toolswith which to uncover the molecular mechanisms of physiological and pathologicalprocesses and might also be useful for diagnosis. We developed such a novel fluorescenceprobe, operating in the physiologically favorable near-infrared region.