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Neuropathic pain-related molecules regulated by P2X4R in microglia

Neuropathic pain-related molecules regulated by P2X4R in microglia
小胶质细胞中 P2X4R 调节的神经病理性疼痛相关分子
批准号:
20689030
负责人:
TSUDA Makoto
金额:
$16.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The aim of the present study was to identify microglial genes whose expression are regulated by P2X4Rs, a receptor crucial for neuropathic pain, and to investigate the role of these molecules in neuropathic pain. The present study found P2Y12 receptor and chemokines as the candidate genes. We also showed an important role of P2Y12 receptor in neuropathic pain and a new mechanism for P2X4R trafficking to the plasma membrane through the chemokine receptor CCR2. Thus, it is possible that targeting P2X4R-regulating genes and P2X4 trafficking may be new therapeutic strategy for treating neuropathic pain.
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DOI: 10.1186/1744-8069-5-28
发表时间: 2009-06-11
期刊: Molecular pain
影响因子: 3.3
作者: [Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K]
通讯作者: Inoue K
ミクログリアと疼痛
小胶质细胞和疼痛
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [津田誠, 井上和秀]
通讯作者: 井上和秀
血小板由来増殖因子PDGF誘発アロディニアにおける脊髄ミクログリアの関与
脊髓小胶质细胞参与血小板源性生长因子 PDGF 诱导的异常性疼痛
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [増田潤哉, ら]
通讯作者:
帯状疱疹関連痛の急性期疼痛の予防又は治療剤
带状疱疹相关急性疼痛的预防或治疗剂
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: []
通讯作者:
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