The functional analysis of key molecule in axon formation, CRMP-2

大脑由非常精细的神经回路组成。这种电路是由轴突组成的，而CRMP-2先前被认为是轴突形成的关键分子。我分析了CRMP-2在轴突形成中的功能意义，得到以下结果：1)CRMP-2通过与Slp1和Rab27的关联调节轴突中TrkB的顺行运输。2) CRMP-2直接与细胞质动力蛋白（一种逆行运输的动力蛋白）结合，负向调控其功能。这些结果表明，CRMP-2通过调节轴突内的分子运输，在轴突形成中发挥作用。

The brain consists of the remarkably fine neural circuits. This circuits are made of axons, and CRMP-2 previously had been identified as a key molecule in axon formation. I analyzed the functional meaning of CRMP-2 in axon formation, and obtained the following results : 1) CRMP-2 regulates anterograde TrkB transport in axon through the association with Slp1 and Rab27. 2) CRMP-2 binds directly to cytoplasmic dynein, a motor protein of retrograde transport, and negatively regulates its function. These results suggest that CRMP-2 play a role in axon formation through regulating the molecular transport in axon.