Oligomerization of SNARE complex by complexin

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Fast, submillisecond synaptic transmission is critical for brain function. Synaptic transmission is mediated by neurotransmitters that are exocytotically discharged by the fusion of synaptic vesicles with the presynaptic membrane. The SNARE complexe is a key step in vesicle fusion. On the other hand, synaptotagmin 1 is essential as a Ca^<2+> sensor. For Ca^<2+>-dependent exocytosis, the strong binding of SNARE complex and synaptotagmin1 is important. However, the affinity between SNARE complex and synaptotagmin1 is very low. The additional factors are needed for this interaction. One candidate for such factors includes synaphins. I reported that synaphin bound to SNARE complex in its central region and synaptotagmin 1 in C-terminal region. These results suggested that synaphin mediated the interaction between SNARE complex and synaptotagmin for Ca^<2+>-dependent exocytosis.