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Functional difference and relationship between cerebrum and cerebellum for bimanual coordination

大脑和小脑在双手协调方面的功能差异和关系

基本信息

批准号：
20700478
负责人：
TOMATSU Saeka
金额：
$ 2.25万
依托单位：
Tokyo Metropolitan Organization for Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2009
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700478/
关键词：
脳高次機能学両手協調小脳大脳両手協調動作連関機能差

项目摘要

The purpose of this study project was to reveal how the cerebrum and the cerebellum share and correlate functions to perform bimanual coordination. Two fMRI studies of human participants revealed that both the cerebral motor-related areas and the cerebellar motor-related areas exhibited activity patterns which reflect temporal patterns of movements, and that all the areas were clearly activated for bimanual coordination. The extracellular recording of cerebellar neuron of monkey performing a step tracking task with its wrist joint revealed that the cerebellum receives the same input as output of the primary motor cortex and the premotor area via mossy fibers during upper limb movement. Moreover, it is possible to say that the cerebellar input layer sharpen the input to convey specific information to Purkinje cells. The neurons in the deep cerebellar nuclei exhibited different functions for movement execution with location, that is, location of their projection. Therefore, it is suggested that the cerebrum and the cerebellum make several loops of function corresponding to the phases of movement execution, and that such control system also work in bimanual coordination.

该研究项目的目的是揭示大脑和小脑如何共享和关联功能以执行双手协调。两项针对人类参与者的功能磁共振成像研究表明，大脑运动相关区域和小脑运动相关区域都表现出反映运动时间模式的活动模式，并且所有这些区域都明显被激活以进行双手协调。对用腕关节执行步数跟踪任务的猴子小脑神经元的细胞外记录显示，在上肢运动过程中，小脑通过苔藓纤维接收与初级运动皮层和前运动区的输出相同的输入。此外，可以说小脑输入层锐化输入以将特定信息传递给浦肯野细胞。小脑深部核团中的神经元根据位置（即它们的投影位置）表现出不同的运动执行功能。因此，建议大脑和小脑形成与运动执行阶段相对应的多个功能循环，并且这种控制系统也可以在双手协调下工作。