The effect of oxidative protein modification on impairment of energy metabolism in skeletal muscle with aging

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c57BL/6 mice kept with free access to chow and sedentary to old age show lipid accumulation and impairment of glucose tolerance as well as oxidative damage in skeletal muscle. In this study, we investigated oxidative protein modification in skeletal muscle associated with impairment of energy metabolism using the animal model as a model of glucose metabolism disorder. Consequently, it has been shown that nitration of tyrosine residues in adenylate kinase 1, which regulates intracellular AMP content, was increased. This may lead to the impairment of glucose uptake in skeletal muscle via lower activity of AMP-activated protein kinase in old mice.