Investigation on the preventive effect of the novel myokine Sparcon colon tumorigenesis

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We found a novel muscle-secreted protein, secreted protein acidic and rich in cysteine (SPARC). In this study, I have examined the preventive effect of the novel myokine SPARC on colon tumorigenesis using SPARC-null mouse. As a result, regular low-intensity exercise significantly reduced the formation of the precursor lesions of colon adenocarcinoma in wild-type mice, whereas exercise did not have an inhibitory effect. In addition, regular exercise increased apoptotic activity in the colon of wild-type mice; however, the activity did not differ between sedentary and exercised SPARC-null mice. These results suggest that the secreted-protein SPARC may suppress proliferation of colon tumor cells via increasing caspase activity.