Inhibitory effect of flavonoids on monocyte adhesion to endothelial cells

柑橘类黄酮如圣草酚和橙皮素通过抑制NF κ B失活的粘附分子来抑制单核细胞与内皮细胞的粘附。柑橘类黄酮可降低同型半胱氨酸诱导的单核细胞活性氧的产生、抗氧化酶和炎性细胞因子的表达以及与内皮细胞的粘附。柑橘类黄酮可抑制内皮细胞和单核细胞的活化，提示其抑制作用可能与抗血管炎症有关。

Citrus flavonoids such as eriodictyol and hesperetin inhibited monocyte adhesion to endothelial cells via suppressing adhesion molecules by NFkB inactivation. Homocysteine-induced ROS production, expression of anti-oxidant enzyme and inflammatory cytokine, and adhesion to endothelial cells were decreased by citrus flavonoids in monocyte. Citrus flavonoids inhibited the activation of endothelial cells and monocyte, suggesting that their inhibitory effect may contribute to protect against vascular inflammatory.