Screening for anti-aging substances from food and natural product extracts using Saccharomyces cerevisiae mutation assay.

白藜芦醇（3,4'，5-三羟基苯乙烯；RSV）是一种多酚，在花生皮和花生藤中含量特别高。本文研究了RSV对酿酒酵母7B株的抗诱变作用。结果表明，RSV预处理24 h可降低致突变率。因此，酿酒葡萄球菌7B暴露于RSV可诱导抗衰老作用。这一结果引起了人们对RSV对人类健康潜在有益影响的强烈兴趣。

Resveratrol (3,4',5-trihydroxystilbene ; RSV) is a polyphenol found in particularly high concentrations in peanut skin and vine. Here we investigated the anti-mutagenic effects of RSV in Saccharomyces cerevisiae strain 7B. Our results showed that RSV pretreatment for 24 h decreased mutagenesis. Thus the exposure of S. cerevisiae 7B to RSV induces an anti-aging effect. This result raises intense interest for the potentially beneficial effects of RSV on human health.