Manipulation and nano-measurement of the structural fluctuation of biomolecules.

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Protein hydration is an important factor for structural formation and enzyme activity. To study the effects of hydration, it is desirable to monitor protein structures or biological activities by modulating the intermolecular interaction between protein and water molecules. In this study, we have developed a novel microscopy for visualizing the pressure-induced changes in the structure and function of biomolecules. We demonstrated that the rotational movement of molecular motors is successively detected with nanometer spatial resolution at high pressure.