Highly sensitive detection of fluorescence with an optical waveguide substrate and polarized excitation light

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Fluorescence from an optical waveguide substrate fabricated with a metal and a dielectric was known to be enhanced more than 100 factors. It has been found in recent year that the fluorescence enhancement depends on the polarization of excitation light. Motivated by this finding, we attempted to develop an instrument for highly sensitive detection of fluorescence employing the polarization dependence of the optical waveguide substrate. As a result, approximately 10-times increase of the sensitivity and S/N ratio could be achieved.