Development of Chip Electrophoresis-Laser Spray Ionization Mass Spectrometry Using Gold Nanoparticles

在这项研究中，激光喷雾电离质谱（LSIMS）的发展，使用金纳米粒子的纳米喷雾直接集成电泳芯片进行了研究。通过注入模式将含有金纳米颗粒的样品溶液从纳米喷雾引入MS检测器。当532 nm CW激光照射到纳米喷雾的尖端时，在负模式下观察到MS信号强度增加12倍。因此，它表明，使用金纳米粒子的LSI-MS给出了阴离子分析物的MS信号增强。

In this study, development of laser spray ionization-mass spectrometry (LSIMS) using gold nanoparticles was investigated on nanospray directly integrated electrophoresis chips. A sample solution containing gold nanoparticles was introduced from the nanospray to the MS detector by the infusion mode. When a 532-nm CW-laser was irradiated to the tip of the nanospray, 12-fold increase in the MS signal intensity was observed in the negative mode. Therefore, it was revealed that LSI-MS using gold nanoparticles gave the MS signal enhancements for anionic analytes.