Development of a Measurement Method for Heat and Electrical Characteristic of a Red Blood Cell

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A microsensor that can measure the electrical impedance and deformability of a single red blood cell (RBC) using microchannels and membrane-type micro-electrodes was successfully developed in this study. Normal human RBC and glutaraldehyde treated rigidified RBC were used as samples to evaluate the validity and accuracy of the sensor. The RBCs were guided to the electrodes in high accuracy, and the impedance and resistance of the each cell could be measured continuously. Moreover, a novel method that can measure the deformability of the RBC by analyzing the time-series distribution of the resistance was proposed, and its validity was confirmed.