Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation

脐带血移植后针对肿瘤抗原和同种异体抗原的免疫反应

• 批准号: 20890096
• 负责人: NISHIDA Tetsuya
• 金额: $ 2.11万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890096/
• 关键词: 臍帯血移植; 腫瘍反応性T細胞; 抗原提示細胞; 成人T細胞性白血病; サイトメガロウイルス; CTLA-4; 抗原特異的T細胞; 臍帶血移植

Immune reaction against tumor-antigen and allo-antigen after cord blood transplantation was analyzed using adult T cell leukemia (ATL) cells. ATL cells activated with CD3/CD28 maintained characteristics of ATL and acquired the potential as an antigen presenting cells. ATL reactive T cells were not generated from post-transplant peripheral blood mononuclear cells isolated from ATL patients with clinical response. Immune reaction against cytomegalovirus after cord blood transplantation was also weaker than that after bone marrow transplantation and peripheral blood stem cell transplantation

用成人T细胞白血病（ATL）细胞分析脐血移植后对肿瘤抗原和同种异体抗原的免疫反应。经CD 3/CD 28活化的ATL细胞保持了ATL的特性，并获得了作为抗原提呈细胞的潜能。从具有临床应答的ATL患者中分离的移植后外周血单核细胞不产生ATL反应性T细胞。脐血移植后抗巨细胞病毒的免疫反应也弱于骨髓移植和外周血干细胞移植

项目成果

Tetsuya Nishida Effect of Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) Haplotype on Allogeneic Hematopoietic Stem Cell Transplantation

西田哲也 细胞毒性 T 淋巴细胞抗原 4 (CTLA-4) 单倍型对同种异体造血干细胞移植的影响

• 发表时间: 2010
• 作者: Kawakami K;Jin M.;et al.;Miho Murase
• 通讯作者: Miho Murase

HLA-A, B, DRBI遺伝子学的適合非血縁者間骨髄移植に対するFK506とCyclosporine Aを用いたGVHD予防法の臨床第III相試験

使用FK506和环孢素A预防GVHD用于HLA-A、B、DRBI基因匹配的无关骨髓移植的III期临床试验

• 发表时间: 2009
• 作者: Kawakami K;Jin M.;et al.;Miho Murase;西田徹也
• 通讯作者: 西田徹也