Development of the prevention for the esophageal stenosis after endoscopic resection of all circumferences for early esophageal cancer

早期食管癌内镜全周切除术后食管狭窄的预防研究进展

• 批准号: 20890125
• 负责人: TOYONOGA Takashi
• 金额: $ 2.11万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890125/
• 关键词: 早期食道癌; バイオマテリアルシート; 生体ブタモデル; 内視鏡的粘膜下層剥離術; 食道がん; 狭窄モデル; 早期食道がん全周性切除後狭窄

In digestive endoscopy field aspiring to less invasive therapy, especially extensive endoscopic submucosal dissection (ESD), the stenosis after ESD is a serious problem. In this study, we examine the prevention for extensive ESD for early esophageal cancer using chitin-containing biomaterial sheets derived from yeast. We succeeded in developing of the esophageal stenosis model after extensive ESD and confirmed the effectiveness of the biomaterial sheets for subcutaneous implantation model using a living pig. In the digestive tract, it was difficult to fix the sheets on the ulcer, we are making the improvement of the raw material and further device.

在追求微创治疗的消化内镜领域，尤其是广泛内镜黏膜下剥离术（ESD）后的狭窄是一个严重的问题。在这项研究中，我们研究了预防广泛的ESD早期食管癌使用甲壳素含生物材料片来自酵母。我们成功地开发了广泛ESD后的食管狭窄模型，并使用活体猪证实了生物材料片用于皮下植入模型的有效性。在消化道中，很难将床单固定在溃疡上，我们正在改进原材料和进一步的设备。