Novel roles of CYLD in the molecular pathogenesis of intractable diseases

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Tumor suppressor CYLD has been recently shown to play important roles in the pathogenesis of various intractable diseases. In the present study, we focused on the CYLD-related diseases (1. lung fibrosis, 2. chronic obstructive pulmonary disease, 3. familial amyloidotic polyneuropathy) and revealed that CYLD acted as a deubiquitinase and involved in various diseases by suppressing intracellular signaling, such as TGFβ signal and NF-κB signal to regulate the disease-related gene expression.