Novel roles of chronic inflammatory factor CYLD in lung fibrosis

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Lung Fibrosis, a fatal progressive pathological condition caused by chronic inflammation, is deeply-involved in the pathogenesis of various kinds of pulmonary diseases. In this study, we focused on CYLD, a novel chronic inflammatory factor, and elucidated the molecular pathogenesis of lung fibrosis. We revealed that, 1. Loss of CYLD promoted lung fibrosis via overproduction of fibrotic response gene, 2. Loss of CYLD caused overproduction of fibrotic response gene via increasing Smad3 protein expression by suppressing Smad3 degradation. Those results suggest that CYLD regulates the fibrotic response gene expressopn and plays important roles in the molecular pathogenesis of lung fibrosis.