A study on oral function of hyposalivation models

用小鼠离体颌下骨灌流技术分析M受体激动剂对体液分泌的影响。降低体温会导致流口水减少。此外，增加灌注液的渗透压可减少液体的分泌。对液体分泌至关重要的通道、受体和转运体的药物抑制也抑制了液体分泌。体外分泌唾液中的离子浓度结果表明，不同的低吸毒症模型的唾液离子组成不同。结果表明，离子浓度分析可能有助于识别引起低活度的靶点。

Fluid secretion in response to muscarinic agonists was analyzed using a mouse ex vivo submandibular perfusion technique. Lowering the temperature from the body temperature induced less salivation. Also, increasing the osmolarity in perfusion solution caused less fluid secretion. Pharmacological inhibition on channels, receptors and transporters crucial for fluid secretion also inhibited fluid secretion. Ion concentrations in secreted ex vivo saliva turned out their ion compositions were different among hyposalivaiton models. The results suggest that ion concentration analysis might work for identifying the target which causes hyposalivation.