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Synthetic Studies on Novel, Natural Anti-Mitotic Agents, Nigricanosides, toward Elucidation of Their Stereochemistry and Biological Activity

Synthetic Studies on Novel, Natural Anti-Mitotic Agents, Nigricanosides, toward Elucidation of Their Stereochemistry and Biological Activity
新型天然抗有丝分裂剂黑芥苷的合成研究,以阐明其立体化学和生物活性
批准号:
21510218
负责人:
FUJIWARA Kenshu
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

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中文摘要
翻译
黑油苷是一种从黑油绿藻中分离出来的单半乳糖二酰基甘油类化合物,具有抑制癌细胞生长的活性。由于天然来源的稀缺和未知的立体化学,黑子皂苷尚未在生物学上进行详细的探索。因此,旨在阐明其立体化学和生物活性的研究已经开始部分合成其同系物,黑油苷a二甲酯。结果,建立了两个醚键的构造方法,并澄清了半乳糖部分与下酰基链之间的醚连接的立体化学性质。
英文摘要
Nigricanoseides, isolated from the green alga Avrainvillea nigricans, belong to a monogalactosyldiacylglycerol family and exhibit potent growth inhibitory activity against cancer cells. Because of the scarce supply from natural source and the unknown stereochemistry, nigricanosides are not explored biologically in detail. Therefore, studies aiming at the elucidation of their stereochemistry and biological activity have commenced with the partial synthesis of a congener, nigricanoseide A dimethyl ester. As a result, methods for the construction of the two ether linkages have been established, and the stereochemistry of the ether junction between the galactose moiety and the lower acyl chain has been clarified.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kenshu Fujiwara, Ayako Kawai, Naoto Kinashi, Hidetoshi Kawai, and Takanori Suzuki]
通讯作者: and Takanori Suzuki
Improved synthesis of C8-C20 segmentof pectenotoxin-2.
改进果胶毒素-2 C8-C20 片段的合成。
DOI: 10.1016/j.tetlet.2011.08.051
发表时间: 2011
期刊: Tetrahedron Lett
影响因子: 1.8
作者: [Kenshu Fujiwara, Yuki Suzuki, Nao Koseki, Shun-ichi Murata, Akio Murai, Hidetoshi Kawai, and Takanori Suzuki]
通讯作者: and Takanori Suzuki
DOI: 10.1016/j.tetlet.2010.06.103
发表时间: 2010-08-25
期刊: TETRAHEDRON LETTERS
影响因子: 1.8
作者: [Fujiwara, Kenshu, Tanaka, Keita, Suzuki, Takanori]
通讯作者: Suzuki, Takanori
DOI: 10.1016/j.tetlet.2010.06.026
发表时间: 2010-08-11
期刊: TETRAHEDRON LETTERS
影响因子: 1.8
作者: [Fujiwara, Kenshu, Hirose, Yuta, Suzuki, Takanori]
通讯作者: Suzuki, Takanori
9
    Synthetic Studies on Anti-Mitotic Natural Products, Nigricanosides, and Their Artificial Analogues for Biological Evaluation
    • 批准号:
      24510289
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.58万
    • 财政年份:
      2012
    • 负责人:
      FUJIWARA Kenshu
    • 依托单位:
    Studies toward Determination of Absolute Stereochemistry and Total Synthesis of Stereochemically Undefined Bioactive Natural Polyether Macrolides
    • 批准号:
      16510152
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.56万
    • 财政年份:
      2004
    • 负责人:
      FUJIWARA Kenshu
    • 依托单位:
    Total Synthesis and Absolute Structure Determination of Marine Polyether Macrohdes.
    • 批准号:
      14580606
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2002
    • 负责人:
      FUJIWARA Kenshu
    • 依托单位:
    国内基金
    海外基金
    蛾类性信息素 E11-14:Ac 合成关键脱饱和酶的分子改造及植物生物合成体系构建
    • 批准号:
      ZCLZ26C1401
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      侯晓青
    • 依托单位:
    新型喹唑啉酮类EGFR抑制剂设计、合成及抗肿瘤生物活性检测
    二氟甲基取代苯并噻吩的制备工艺研发
    • 批准号:
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      张东
    • 依托单位:
    提高银杏叶片愈伤组织黄酮含量的培养基研发
    • 批准号:
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      张海啸
    • 依托单位: