Total Synthesis and Absolute Structure Determination of Marine Polyether Macrohdes.

研究了海洋聚醚大环内酯类化合物的全合成和立体化学配位新方法。本课题以扇贝（Patinopecten yessoensis）和鞭毛藻（Dinophysis fortii）中分离的腹泻贝类毒素pectenotoxin 2和鞭毛藻Alexandrium hiranoi （Goniodoma pseudogoniulax）中分离的抗真菌剂goniodomin a为合成靶点。Pectenotoxin 2计划在其全合成的最后阶段从其1-epi同系物中衍生出来。以C1-C7、C8-C20、C21-C30和C31-C40四段为原料，经过磺酸偶联、缩醛环化、烯烃闭环复分解等聚合反应，成功合成了7-外延-pectenotoxin 2的全保护形式。计划部分合成性腺蛋白A进行立体化学配位。建立了C1-C7、C6-C16、C15-C25和C31-C36片段的合成。

New methodologies for total synthesis and stereochemical assignment of marine polyether macrolides were investigated. In this project, pectenotoxin 2,a diarrhetic shellfish toxin isolated from scallop Patinopecten yessoensis and dinoflagellate Dinophysis fortii, and goniodomin A, an antifungal agent isolated from dinoflagellate Alexandrium hiranoi (Goniodoma pseudogoniaulax), were selected as the synthetic targets. Pectenotoxin 2 was planned to be derived from its 1-epi congener at the final stage of its total synthesis. Full-protected form of the 7-epi-pectenotoxin 2 was successfully synthesized from four segments corresponding to the C1-C7,C8-C20,C21-C30 and C31-C40 parts, through a convergent process including sulfone-coupling, acetal-cyclization, and-ring-closing-olefin-metathesis reactions. Partial synthesis of goniodomin A was planned for the stereochemical assignment. Synthesis of the C1-C7,C6-C16,C15-C25, and C31-C36 fragments were established.