Micro-Scale Sample Preparation Devices for Novel Non-Invasive Screening Diagnosis with Human Breath Samples

在这项工作中，开发了一种新的非侵入性诊断技术，利用人体呼气样本进行糖尿病患者的筛查。所开发的针式样品制备方法具有存储性能好、采样过程中操作简单等优点。呼气样品中的丙酮浓度与酮体的总浓度之间以及丙酮浓度与血液中的HbA1c%之间存在良好的相关性，这表明该技术是一种成功的快速筛查技术。

In this work, a novel non-invasive diagnosis technique with human breath sample was developed for the screening of diabetic patients. The developed needle-type sample preparation method has several advantageous features such as an excellent storage performance and easy operations during the sampling process. The correlation between the acetone concentration in breath samples and the total concentrations of ketone bodies was confirmed along with a good correlation between the acetone concentration and the HbA1c% in blood, suggesting a successful development of this technique as a quick screening technique.