Micro-Scale Sample Preparation Devices for Novel Non-Invasive Screening Diagnosis with Human Breath Samples

用于利用人体呼吸样本进行新型非侵入性筛查诊断的微量样品制备装置

• 批准号: 21550078
• 负责人: SAITO Yoshihiro
• 金额: $ 3.16万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21550078/
• 关键词: 試料処理; 呼気診断; 非侵襲診断; マイクロ化; 針型デバイス; 糖尿病; 抽出; 試料前処理; 呼気分析; マイクロ抽出法; 高感度検出; ガスクロマトグラフィー; 非侵襲診断技術; 空気環境測定

In this work, a novel non-invasive diagnosis technique with human breath sample was developed for the screening of diabetic patients. The developed needle-type sample preparation method has several advantageous features such as an excellent storage performance and easy operations during the sampling process. The correlation between the acetone concentration in breath samples and the total concentrations of ketone bodies was confirmed along with a good correlation between the acetone concentration and the HbA1c% in blood, suggesting a successful development of this technique as a quick screening technique.

在这项工作中，一种新的非侵入性诊断技术与人类呼吸样本的糖尿病患者的筛选。所开发的针式样品制备方法具有几个有利的特点，如良好的存储性能和易于操作的采样过程中。呼吸样本中丙酮浓度与酮体总浓度之间的相关性得到证实沿着丙酮浓度与血液中HbA1c %之间具有良好的相关性，这表明该技术作为快速筛查技术的成功开发。

项目成果

Development of Novel Fiber-Packed Needle Interface for Off-Line Reversed-Phase Liquid Chromatography-Capillary Gas Chromatography

用于离线反相液相色谱-毛细管气相色谱的新型纤维填充针接口的开发

• 发表时间: 2009
• 期刊: Journal of Chromatography A
• 影响因子: 4.1
• 作者: A. Abe;Y. Saito;I. Ueta;K. Nakane;T. Takeichi and K. Jinno
• 通讯作者: T. Takeichi and K. Jinno

Rapid Temperature-Programmed Separation and Retention Prediction on Novel Packed-Capillary Column in Gas Chromatography

气相色谱中新型填充毛细管柱的快速程序升温分离和保留预测

• 发表时间: 2010
• 期刊: Analytical Sciences
• 影响因子: 1.6
• 作者: I. Ueta;Y. Saito;K. Teraoka;T. Miura;K.Jinno;;M.Inoue
• 通讯作者: M.Inoue

Determination of Bisphenol A in Water Using a Packed Needle Extraction Device

使用填充针萃取装置测定水中的双酚 A

• 发表时间: 2009
• 期刊: Chromatographia
• 影响因子: 1.7
• 作者: M. Ogawa;Y. Saito;S. Shirai;Y. Kisoand K. Jinno
• 通讯作者: Y. Kisoand K. Jinno

Sample Preparation Device for Human Breath Analysis in Capillary Gas Chromatography

毛细管气相色谱人体呼吸分析样品制备装置

• 发表时间: 2010
• 作者: I. Ueta;Y. Saito;K. Teraoka;T. Miura;K.Jinno;;M.Inoue;Y.Saito;Y. Saito;;近藤功行;Y. Saito
• 通讯作者: Y. Saito

マイクロ試料前処理技術の新展開

微量样品前处理技术新进展

• 发表时间: 2010
• 作者: Zhongqi Xu;K.Kawahito;X.Ye;A.E.Timerbaev;T.Hirokawa;齊戸美弘
• 通讯作者: 齊戸美弘