DNA-chip-based gene sensor based on in-situ electronical functionalization of double-helical DNA self-assemblies.

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DNA-based molecular device tackled for futuristic gene sensor developmentsbased on in-situ electroconductivemodification of wasDNA self-assembly. Some direct or indirect assistance necessary to the goal were successfully developed ; novel small-molecule, reative compounds that enable versatile functionalization of DNA duplexes, scanning electrochemical microscopy imaging of DNA microdots, a new potentiometric platform for gene sensing, and etc. Unfortunately, the planned strategy, dip-pen nanolithography, has not yet achieved mostly due to the mechanical instability of the DNA self-assemblies. However, are committed to taking on the challengesbyusingsome DNAnanomaterialstoprovidetheparticulawergene-sensing device.