Development of chiral organo catalysts in which different atoms cooperatively catalyze asymmetric reactions

点击翻译按钮获取中文摘要

A novel asymmetric organocatalyst for preparation of optically active alcohol derivatives has been developed. The catalyst is a phosphinite derivative easily derived from aminoindanol whose both enantiomers are commercially available. Especially, asymmetric desymmetrization of 1, 2-diols by use of acylation reaction catalyzed by the organocatalyst gave desired chiral alcohol derivatives with high enantioselectivity and in high yield. In addition, kinetic resolution of racemic alcohols such as cyclohexylbenzyl alcohol was achieved with high level of resolution efficiency.