Synthesis of Cyclophane Oligomers Having Multivalently Enhanced Guest-Binding Affinity Based on Cluster Effect

基于簇效应的多价增强客体结合亲和力的环芳低聚物的合成

• 批准号: 21550136
• 负责人: HAYASHIDA Osamu
• 金额: $ 3.16万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21550136/
• 关键词: ホストゲスト化学; シクロファン; クラスター効果; ホストゲスト; 分子認識

Water-soluble cyclophane dimer, trimer, tetramer, and pentamer were prepared by aminolysis of succinimidyl ester derivative of tetraaza[6.1.6.1] paracyclophane with lysine and the corresponding lysine peptide as a scaffold, followed by removal of the protecting groups. The present cyclophane oligomers showed enhanced guest-binding affinities toward fluorescent guests such as 6-p-toluidino-naphthalene-2-sulfonate, in comparison with those of monocyclic cyclophane, reflecting multivalency effects in macrocycles. The effects of multivalent macrocycles on the guest-binding of the present cyclophane oligomers were also confirmed by SPR measurements.

水溶性环蕃二聚体、三聚体、四聚体和五聚体是通过用赖氨酸和相应的赖氨酸肽作为支架氨解四氮杂[6.1.6.1]对环蕃的琥珀酰亚胺基酯衍生物，然后除去保护基团来制备的。本环蕃低聚物显示出增强的客人结合亲和力对荧光客人，如6-对甲苯胺基-萘-2-磺酸酯，与那些单环环蕃相比，反映在大环的多价效应。SPR测量也证实了多价大环化合物对本环蕃低聚物的客体结合的影响。

项目成果

タンパク質の表面認識能を有するシクロファン集積型ホストの合成

具有蛋白质表面识别能力的环芳整合宿主的合成

• 发表时间: 2009
• 作者: Hideki Okamoto;(他2名);林田修
• 通讯作者: 林田修

Surface Plasmon Resonance Study on Binding Interactions of Multivalent Cyclop hane Hosts with Immobilized Guests

多价环烷主体与固定客体结合相互作用的表面等离子体共振研究

• 发表时间: 2009
• 期刊: Polym. Adv. Technol. 20(in press)
• 作者: O. Hayashida;D. Sato
• 通讯作者: D. Sato

Synthesis and Characterization of Coordination Polymers of A Carboxylato Cyclophane with Metal[Zn(II)and Cd(II)]-2, 20-Bipyridines

羧基环芳与金属[Zn(II)和Cd(II)]-2, 20-联吡啶配位聚合物的合成与表征

• 发表时间: 2010
• 期刊: Polyhedron
• 影响因子: 2.6
• 作者: H.Yonemura;et al.;Osamu Hayahsida
• 通讯作者: Osamu Hayahsida

ペプチドを基本骨格としたシクロファン多量体の合成とゲスト捕捉能の比較評価

以肽为基本骨架的环芳多聚体的合成及客体捕获能力的对比评价

• 发表时间: 2012
• 作者: 岡本秀毅;佐藤温子;佐竹恭介;中島智美・中村勇気・林田修
• 通讯作者: 中島智美・中村勇気・林田修

Preparation and multivalently enhanced guest-binding affinity of peptide-based cyclophane oligomers

基于肽的环芳低聚物的制备和多价增强的客体结合亲和力

• 发表时间: 2010
• 作者: Tomomi Nakashima;Osamu Hayashida
• 通讯作者: Osamu Hayashida