Ultrastructural analysis of newly indentified membrane structure in autophagy

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Autophagy is one of the intracellular degradative process. In this process, cells sequester their own cytoplasmic components into a novel double-membrane structure which is newly formed in cytoplasm, and then transport it into the lytic compartment for the reuse. Autophagy defective yeast mutants were isolated by genetic screening. To investigate how these membrane structures are generated during autophagy, I observed intracellular structure of autophagy defective mutants by using an electron microscope. As a result, I found the initial stage of this membrane structure.