Central nervous system controlling drinking behavior in seawater eels : from hormone reception to esophageal muscle contraction

控制海水鳗饮水行为的中枢神经系统：从激素接收到食管肌肉收缩

• 批准号: 21570078
• 负责人: ANDO Masaaki
• 金额: $ 3.16万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570078/
• 关键词: 飲水調節ホルモン; Area postrema(AP); 神経活動; Glossopharyngeal-vagal motor complex(GVC); 飲水行動; 最後野(AP1); 脳弓下器官(SFO); 迷走神経運動核(GVC 1); アンギオテンシン; カテコールアミン; 心房性ナトリウム利尿ペプチド; アンギオテンシンII; クモ膜剥離; 最後野; 腹側視索前野; 血液脳関門; ユニットスパイク; 海水ウナギ; Angiotensin II; Atrial

Neurons in the area postrema(AP, especially at AP1 region) of the medulla oblongata of the eel was excited by angiotensin II(ANG II), and the ANG II-induced AP1 excitation inhibited the neuronal activity of the glossopharyngeal-vagal motor complex(GVC, especially at GVC1 region). On the other hand, atrial natriuretic peptide(ANP) inhibited the ANG II-induced AP1 excitation. Similar interaction between ANG II and ANP has been reported in the subfornical organ of the rat, therefore it is likely that these dipsogenic(ANG II) and antidipsogenic(ANP) hormones act on the AP1 in the eel. ANG II may facilitate the drinking rate by exciting the AP1 activity, which inhibits the GVC1 activity, which relaxes the upper esophageal sphincter muscle, thus enhance the water intake into the esophagus.

血管紧张素Ⅱ（ANG Ⅱ）可兴奋鳗鱼延髓最后区（AP，尤其是AP 1区）神经元，而ANG Ⅱ引起的AP 1兴奋可抑制舌咽-迷走神经运动复合体（GVC，尤其是GVC 1区）神经元的活动。另一方面，心房钠尿肽（ANP）抑制ANG II诱导的AP 1兴奋。在大鼠穹窿下器官中已报道ANG II和ANP之间存在类似的相互作用，因此这些致渴（ANG II）和抗渴（ANP）激素可能作用于鳗鱼中的AP 1。ANG Ⅱ可能通过激活AP 1活性，抑制GVC 1活性，使食管上括约肌松弛，从而增加食管的水分摄入，从而促进饮水速率。

项目成果

Central regulation of the pharyngeal and upper esophageal reflexes during swallowing in the Japanese eel

日本鳗鱼吞咽过程中咽部和上食管反射的中枢调节

• DOI: 10.1007/s00359-009-0498-4
• 发表时间: 2010
• 期刊: J. Comp. Physiol
• 作者: Nojima T;Kimura K-I;Koganezawa M;Yamamoto D.;Mukuda Takao and Ando Masaaki
• 通讯作者: Mukuda Takao and Ando Masaaki

Guanylin enhances Cl-permeability across the intestine of the eel acclimated to sea water

鸟苷素增强了适应海水的鳗鱼肠道的 Cl 渗透性

• 发表时间: 2011
• 作者: Ando;M.;and Takei;Y.
• 通讯作者: Y.

海水ウナギの腸における塩と水の輸送に及ぼすグアニリンの作用

鸟苷酸对海水鳗肠道盐和水转运的影响

• 发表时间: 2011
• 作者: 安藤正昭;竹井祥郎
• 通讯作者: 竹井祥郎

Guanylin enhances Cl^- permeability across the intestine of the eel acclimated to sea water

鸟苷素增强了适应海水的鳗鱼肠道的 Cl^- 渗透性

• 发表时间: 2011
• 作者: Ando;M.
• 通讯作者: M.

海水ウナギの延髄最後野ニューロンの飲水調節ホルモンに対する応答

延髓后咸水鳗神经元对饮水调节激素的反应

• 发表时间: 2011
• 作者: Yutetsu Kuruma;Hideaki Matsubayashi;Takuya Ueda;安藤正昭
• 通讯作者: 安藤正昭