Does inhibition of phosphatidylserine synthase induce autophagy?

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To investigate the relation between a defect in phosphatidylserine synthesis and autophagic cell death, we focused on a CHO mutant that has a defect in an activity of phosphatidylserine synthase. When the mutant cells were cultured in a medium lacking phosphatidylserine, LC3-II, a promising autophagic marker, was increased within 24h. At 24-48h after induction of LC3-II, cell viability was decreased. The results suggested that the autophagy play a cytoprotective role, when phsophatidylserine depeletion-induced cell death.