Functional elucidation of IRBIT, a master regulator in the central nervous system

中枢神经系统主调节器 IRBIT 的功能阐明

• 批准号: 21570190
• 负责人: MIZUTANI Akihiro
• 金额: $ 3.08万
• 依托单位: Showa Pharmaceutical University (2011)The Institute of Physical and Chemical Research (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570190/
• 关键词: IRBIT; 多重リン酸化領域; 細胞外環境応答; ストレス反応; 多重リン酸化; 細胞外環境センサー; IP3レセプター; マスター調節因子

IRBIT is highly expressed in the glial processes facing and/or ensheathing synaptic clefts. IRBIT interacts with both IP3 receptor and NBC1 in its phosphorylation dependent manner, and modulates their functions. The phosphorylated residues on IRBIT which binds to IP3R with high affinity were revealed to differ from those of IRBIT which binds to NBC1.

伊尔比特在面对和/或成鞘突触裂隙的神经胶质过程中高度表达。伊尔比特以磷酸化依赖的方式与IP 3受体和NBC 1相互作用，并调节它们的功能。发现伊尔比特上以高亲和力结合IP 3 R的磷酸化残基不同于伊尔比特上结合NBC 1的磷酸化残基。

项目成果

Isolation of inositol 1, 4, 5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference

使用 RNA 干扰分离肌醇 1,4,5-三磷酸受体相关蛋白并选择性敲低

• DOI: 10.1007/978-1-60327-175-2_9
• 发表时间: 2010
• 期刊: Methods Mol Biol
• 作者: Mizutani A;Kawaai K;Hisatsune C;Ando H;Michikawa T;Mikoshiba K
• 通讯作者: Mikoshiba K

Inositol 1,4,5-Triphosphate Receptor-binding Protein Released with Inositol 1,4,5-Triphosphate (IRBIT) Associates with Components of the mRNA 3′ Processing Machinery in a Phosphorylation-dependent Manner and Inhibits Polyadenylation

• DOI: 10.1074/jbc.m807136200
• 发表时间: 2009-04-17
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Kiefer, Helene;Mizutani, Akihiro;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway

• DOI: 10.1172/jci43475
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Yang, Dongki;Li, Qin;Muallem, Shmuel
• 通讯作者: Muallem, Shmuel

Syntaxin 1B Suppresses Macropinocytosis and Semaphorin 3A-Induced Growth Cone Collapse

• DOI: 10.1523/jneurosci.2718-10.2011
• 发表时间: 2011-05-18
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Kabayama, Hiroyuki;Takeuchi, Makoto;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

IRBIT coordinates epithelial fluid and HCO3-secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct

• DOI: 10.1172/jci36983
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Yang, Dongki;Shcheynikov, Nikolay;Muallem, Shmuel
• 通讯作者: Muallem, Shmuel