Possible function of IP3 receptor as a non-channel molecule

IP3受体作为非通道分子的可能功能

• 批准号: 18570122
• 负责人: MIZUTANI Akihiro
• 金额: $ 2.53万
• 依托单位: The Institute of Physical and Chemical Research (2008)The University of Tokyo (2006-2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18570122/
• 关键词: IP3レセプター; IRBIT; 小脳; シナプス可塑性; リン酸化

IP3レセプターに結合し、IP3によって放出されるIRBIT分子のIP3レセプターへの結合に必須な4カ所のリン酸化部位同定に成功した。さらに、IRBITに結合する種々の機能分子の同定にも成功し、IP3レセプター-IRBIT-IRBIT結合蛋白質群による、細胞機能調節機構の存在を明らかにした。

The combination of IP3 and IP3 molecules and the release of IP3 molecules must be consistent with the success of the acidizing site. The identification of several kinds of functional molecules by the combination of DNA and IRBIT, the identification of successful molecular markers, the identification of IRBIT-IRBIT-binding protein clusters and the identification of cellular molecular markers are confirmed by the identification of molecular markers.

项目成果

Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells

• DOI: 10.1523/jneurosci.4738-07.2008
• 发表时间: 2008-05-14
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Mizutani, Akihiro;Kuroda, Yukiko;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

Purkinje細胞におけるHomer3 のリン酸化

浦肯野细胞中 Homer3 的磷酸化

• 发表时间: 2008
• 作者: 水谷 顕洋;黒田有希子;古市 貞一;御子柴克彦
• 通讯作者: 御子柴克彦

IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1)

• DOI: 10.1073/pnas.0602250103
• 发表时间: 2006-06-20
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Shirakabe, Kyoko;Priori, Giuseppina;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor

• DOI: 10.1016/j.molcel.2006.05.017
• 发表时间: 2006-06-23
• 期刊: MOLECULAR CELL
• 影响因子: 16
• 作者: Ando, Hideaki;Mizutani, Akihiro;Mikoshiba, Katsuhiko
• 通讯作者: Mikoshiba, Katsuhiko

The role of Ca2+ signaling in cell function with special reference to exocrine secretion

• DOI: 10.1097/ico.0b013e31817f246e
• 发表时间: 2008-09-01
• 期刊: CORNEA
• 影响因子: 2.8
• 作者: Mikoshiba, Katsuhiko;Hisatsune, Chihiro;Miyachi, Kiyomitsu
• 通讯作者: Miyachi, Kiyomitsu