A potential role of mitochondria-mediated signaling in induction of malignancy and stemness by TGF.

线粒体介导的信号传导在 TGF 诱导恶性肿瘤和干性中的潜在作用。

• 批准号: 21570205
• 负责人: SHIBANUMA Motoko
• 金额: $ 3.08万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570205/
• 关键词: ミトコンドリア; CREB; HMGA2; CHOP-10; TGFβ; 膜電位; 活性酸素; チオレドキシン; プロテインキチーゼC; MMP9

cAMP-responsive element-binding protein(CREB) was found to be activated and cause morphological disruption of epithelial cells under mitochondrial dysfunction. Of note, activated CREB upregulated HMGA2, resulting in activation of epithelial-mesenchymal transition(EMT) program and modulation of integrin. 1 expression. Overall, the results suggest that mitochondrial dysfunction potentially mediates TGF-.-induced malignancy and contributes to neoplastic transformation of epithelial cells.

cAMP反应元件结合蛋白（CREB）被发现被激活，并导致线粒体功能障碍的上皮细胞的形态破坏。值得注意的是，活化的CREB上调HMGA 2，导致上皮-间充质转化（EMT）程序的活化和整联蛋白的调节。1表达式。总之，结果表明线粒体功能障碍可能介导TGF-β 1。诱发恶性肿瘤，并有助于上皮细胞的肿瘤转化。

项目成果

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodering

Hic-5 缺乏增强机械敏感性细胞凋亡并调节血管重塑

• 发表时间: 2011
• 期刊: J.Mol.Cell.Cardiol.
• 作者: Kim-Kaneyama;J.-R.;et.al.
• 通讯作者: et.al.

HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth.

• DOI: 10.1155/2012/426138
• 发表时间: 2012
• 期刊: International journal of cell biology
• 作者: Shibanuma M;Mori K;Nose K
• 通讯作者: Nose K

A mobile molecular scaffold regulating the anchorage dependence of cell growth

调节细胞生长锚定依赖性的移动分子支架

• 发表时间: 2011
• 期刊: Int J. Cell Biol
• 作者: 柴沼質子;森一憲;野瀬清
• 通讯作者: 野瀬清

Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation class lla HDACs.

TGF-β对MMP-10的转录诱导，由MEF2A的激活和IIa类HDAC的下调介导。

• 发表时间: 2010
• 期刊: Oncogene 29
• 作者: Ishikawa;F.;Miyoshi;H.;Nose;K.;Shibanuma;M.
• 通讯作者: M.

Gene expression profiling identifies a role for CHOP-10 during inhibition of the mitochondrial respiratory chain

基因表达谱分析确定了 CHOP-10 在抑制线粒体呼吸链过程中的作用

• 发表时间: 2009
• 期刊: J. Biochem
• 作者: Ishikawa;F.;Akimoto;T.;Yamamoto;H.;Araki;Y.;Yoshie;T.;Mori;K.;Hayashi;H.;Nose;K.;and Shibanuma;M.
• 通讯作者: M.