Regulation of angiogenesis by FOXO transcription factors

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The function of Foxo1, a transcription factor which is essential for vascular development, was investigated by using an ES cell culture system. We found that Foxo1 modulates the morphological response of vascular endothelial cells to various angiogenic stimuli and the recruitment of vascular smooth muscle cells to the endothelium, thereby regulating angiogenesis and vascular maturation. A candidate of the Foxo1 target gene which might be involved in the morphological regulation of endothelial cells has been identified by using a functional screening analysis.