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Induction of hematopoietic stem cells from ES/iPS cellswithout gene manipulation

Induction of hematopoietic stem cells from ES/iPS cellswithout gene manipulation
无需基因操作即可从 ES/iPS 细胞诱导造血干细胞
批准号:
24657157
负责人:
OGAWA Minetaro
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --

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中文摘要
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英文摘要
This study aimed at establishing a defined culture condition whichallows ES cells to differentiate into long-term reconstituting hematopoietic stem cellswithout gene manipulation. Multi-potent hematopoietic progenitor cells were able to beinduced from ES cells in a serum-free culture in the presence of several growth factors andchemicals. When transplanted into lethally irradiated adult mice, however , thesehematopoietic progenitor cells failed to show an ability of long-term reconstitution of bonemarrow hematopoiesis.
期刊论文(8)
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会议论文
Levels of the c-Myb protein indicate repopulating capacity in long-term hematopoietic stem cells.
c-Myb 蛋白的水平表明长期造血干细胞的重新增殖能力。
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Hayashi, T., Yokotani, N., Tane, S.,Matsumoto, A., Myouga, A.,Takeuchi, T., Hiroshi Sakamoto]
通讯作者: Hiroshi Sakamoto
DOI: 10.1161/circresaha.111.259499
发表时间: 2012-01-20
期刊: CIRCULATION RESEARCH
影响因子: 20.1
作者: [Ishida, Masayoshi, El-Mounayri, Omar, Husain, Mansoor]
通讯作者: Husain, Mansoor
微小環境の血液幹細胞への働きかけ-誕生から骨髄での維持まで
微环境对造血干细胞的影响——从出生到骨髓中的维持
DOI: --
发表时间: 2013
期刊: 実験医学
影响因子: --
作者: [坂本比呂志, 田村潔美, 小川峰太郎]
通讯作者: 小川峰太郎
熊本大学発生医学研究所
熊本大学胚胎医学研究所
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
6
    Controlling the differentiation of hemogenic endothelial cells: Toward the derivation of hematopoietic stem cells from ES cells
    • 批准号:
      15K07081
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2015
    • 负责人:
      OGAWA Minetaro
    • 依托单位:
    Regulation of angiogenesis by FOXO transcription factors
    • 批准号:
      21570229
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2009
    • 负责人:
      OGAWA Minetaro
    • 依托单位:
    Induction of cardio-vascular progenitor cells and blood vessel formation by ES cell differentiation.
    • 批准号:
      16390227
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.77万
    • 财政年份:
      2004
    • 负责人:
      OGAWA Minetaro
    • 依托单位:
    Cell biological analyses of vascular remodeling by using an in vitro differentiation system of ES cells
    • 批准号:
      14570658
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      OGAWA Minetaro
    • 依托单位:
    海外基金