Induction of hematopoietic stem cells from ES/iPS cellswithout gene manipulation
Induction of hematopoietic stem cells from ES/iPS cellswithout gene manipulation
批准号:
24657157
负责人:
OGAWA Minetaro
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
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英文摘要
This study aimed at establishing a defined culture condition whichallows ES cells to differentiate into long-term reconstituting hematopoietic stem cellswithout gene manipulation. Multi-potent hematopoietic progenitor cells were able to beinduced from ES cells in a serum-free culture in the presence of several growth factors andchemicals. When transplanted into lethally irradiated adult mice, however , thesehematopoietic progenitor cells failed to show an ability of long-term reconstitution of bonemarrow hematopoiesis.
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Levels of the c-Myb protein indicate repopulating capacity in long-term hematopoietic stem cells.
c-Myb 蛋白的水平表明长期造血干细胞的重新增殖能力。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Hayashi, T., Yokotani, N., Tane, S.,Matsumoto, A., Myouga, A.,Takeuchi, T., Hiroshi Sakamoto]
通讯作者:
Hiroshi Sakamoto
DOI:
10.1161/circresaha.111.259499
发表时间:
2012-01-20
期刊:
CIRCULATION RESEARCH
影响因子:
20.1
作者:
[Ishida, Masayoshi, El-Mounayri, Omar, Husain, Mansoor]
通讯作者:
Husain, Mansoor
微小環境の血液幹細胞への働きかけ-誕生から骨髄での維持まで
微环境对造血干细胞的影响——从出生到骨髓中的维持
DOI:
--
发表时间:
2013
期刊:
実験医学
影响因子:
--
作者:
[坂本比呂志, 田村潔美, 小川峰太郎]
通讯作者:
小川峰太郎
熊本大学発生医学研究所
熊本大学胚胎医学研究所
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Levels of the c-Mybprotein indicate repopulating capacity inlong-term hematopoietic stem cells
c-Myb 蛋白的水平表明长期造血干细胞的重新增殖能力
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Harima, Y, Takashima, Y, Ueda, Y, Ohtsuka, T., and Kageyama, R, 坂本比呂志]
通讯作者:
坂本比呂志
共 6 条
Controlling the differentiation of hemogenic endothelial cells: Toward the derivation of hematopoietic stem cells from ES cells
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批准号:15K07081
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2015
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负责人:OGAWA Minetaro
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依托单位:
Regulation of angiogenesis by FOXO transcription factors
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批准号:21570229
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2009
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负责人:OGAWA Minetaro
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依托单位:
Induction of cardio-vascular progenitor cells and blood vessel formation by ES cell differentiation.
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批准号:16390227
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:2004
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负责人:OGAWA Minetaro
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依托单位:
Cell biological analyses of vascular remodeling by using an in vitro differentiation system of ES cells
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批准号:14570658
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:OGAWA Minetaro
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依托单位:
Manipulation of hematopoietic cell development by expression of transcription factors
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批准号:12670301
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:OGAWA Minetaro
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依托单位:
海外基金