Analysis of the physiological significance of GPI flippase and synthesis
Analysis of the physiological significance of GPI flippase and synthesis
批准号:
21580094
负责人:
FUNATO Kouichi
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Glycosylphosphatidylinositol(GPI) is a complex glycolipid that anchors proteins to the plasma membrane. In this study, using a deletion mutant of ARV1 gene that encodes a putative flippase required for the transport of a GPI intermediate to the ER lumen and other mutants defective in GPI synthesis, we found that GPI synthesis regulates aging and cell death in yeast, and the cell death is largely concerned with structure and function of telomere.
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会议论文
スフィンゴ脂質恒常性の破綻がきたす細胞死誘導機構の解析
鞘脂稳态破坏诱导细胞死亡机制分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[梶原健太郎, 船戸耕一]
通讯作者:
船戸耕一
海外基金