Proteomic approach for identification of lysine acetylation in bacteria

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To understand biological significance of protein(lysine) acetylation in bacteria, we performed acetylome analysis in Bacillus subtilis. We identified 145 acetylated peptides that matched to 120 proteins, which are involved in metabolism and translation as well as essential functions. We identified elongation factor(EF)-Tu as a major acetylated protein, acetylation level of which is differentially regulated in growth phases and medium conditions. We also performed acetylome analysis in Corynebacterium glutamicum.