Effects of dietary protein on immunological activity and host resistance to fungal infection in mice

为了建立寄主抗性的最佳饲料，我们研究了不同饲料蛋白水平对寄主对病原真菌抗性的影响。与正常蛋白饮食的小鼠相比，低蛋白饮食的小鼠在脾和肝脏中显示出更高的抗真菌活性。相比之下，高蛋白饮食的小鼠在这些器官中显示出较低的抗真菌活性。这些结果表明，不营养的蛋白质限制有利于提高寄主对病原真菌的抗性，但高蛋白摄入量会削弱寄主对病原真菌的抗性。

In an effort to establish the optimum diet for host resistance, we investigated the effect of different dietary protein levels on host resistance to pathogenic fungi. Mice refed low protein diet showed higher antifungal activity in the spleen and liver compared with mice on the normal protein diet. In contrast, mice refed high protein diet showed reduced antifungal activity in these organs. The present results imply that protein restriction without malnutrition could be beneficial to host resistance to pathogeni fungi, but high protein intake impairs host resistance.