Beet dietary fiber decreased body fat and increased hypothalamic gene expression of leptin receptor in rats

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Lack of leptin receptor(Ob-Rb) function canceled effects of dietary beet fiber on energy intake and body fat. Ob-Rb might play predominant role in the mechanism. Dietary BF increased hypothalamic Ob-Rb gene expression and modified appetite regulating factors. Vagus nerve blocking technique revealed that brain-gut connection via vagus nerve might not be necessary to effects of dietary beet fiber on energy intake and body fat.