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Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.

Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.
阐明 MT-SP1 在肠上皮更新中的作用并探索控制该分子激活的食物成分。
批准号:
21580138
负责人:
TSUZUKI Satoshi
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We found that a membrane-bound serine protease MT-SP1 induces detachment and apoptosis of intestinal epithelial IEC-6 cells. Also, we found that a recombinant form of MT-SP1 pseudozymogen exhibits a protease activity and that the activity is not seen in the presence of NaCl.
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会议论文
肝細胞増殖因子アクチベーター阻害物質I型(HAI-1)によるマトリプターゼ阻害機構
肝细胞生长因子激活剂抑制剂 I 型 (HAI-1) 抑制 matriptase 的机制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [安元誠, ら, 都築巧]
通讯作者: 都築巧
Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells
猴肾 COS-1 细胞中跨膜丝氨酸蛋白酶基质酶胞外出现对肝细胞生长因子激活剂抑制剂 1 型活性的要求
DOI: --
发表时间: 2009
期刊: Cytotechnology 60
影响因子: --
作者: [Miyake, Y., Tsuzuki, S., Yasumoto, M., Fushiki, T., Inouye, K.]
通讯作者: K.
Matriptaseのstem領域においてHAI-1(hepatocyte growth factor activator inhibitor type 1)との相互作用を容易にする部位の同定
鉴定 Matriptase 茎区中促进与 HAI-1(肝细胞生长因子激活剂抑制剂 1 型)相互作用的位点
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [安元誠, ら]
通讯作者:
The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells
极化上皮细胞中 Matriptase 胞外域释放的结构要求
DOI: 10.1271/bbb.100074
发表时间: 2010
期刊: Bioscience, Biotechnology, and Biochemistry
影响因子: --
作者: [Tsuzuki S, Murai N, Miyake Y, Inouye K, Fushiki T.]
通讯作者: Fushiki T.
19
    Elucidation of the mechanism of matriptase activation and exploration of food components that control the activation.
    • 批准号:
      24580178
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      TSUZUKI Satoshi
    • 依托单位:
    Elucidation of significance of serine proteases found in the intestines on cell death and the mechanism of the proteases-mediated cell death regulated by food components
    • 批准号:
      18580118
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.58万
    • 财政年份:
      2006
    • 负责人:
      TSUZUKI Satoshi
    • 依托单位:
    Studies on the role of granzyme A, a binding molecule for monitor peptide, in the CCK release mediated by the peptide
    • 批准号:
      15580106
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.37万
    • 财政年份:
      2003
    • 负责人:
      TSUZUKI Satoshi
    • 依托单位:
    海外基金